The popular drug alendronate sodium (Fosamax) has been prescribed to millions of people (mostly women) suffering from osteoporosis, a weakening of the bones that often comes with aging. But two new findings indicate that the drug also can cause some significant health problems.
Physicians at Weill Medical College of Cornell University found that Fosamax may increase risk for fractures of the thigh-bone (femur). Researchers reviewed 70 people with femur fractures and identified a type of break specific to patients who had been taking Fosamax for more than four years. (Incidentally, the breaks happened despite the subjects' suffering minimal or no trauma.)
Reason: Fosamax works by inhibiting bone cells known as osteoclasts, which break down bone so it can rebuild itself, and in some patients, this inhibits bone repair.
- The FDA reported earlier this year that Fosamax (and similar drugs) can cause incapacitating pain in bones, joints and/or muscles for reasons unknown.
- A study in Archives of Internal Medicine found that postmenopausal women who had used Fosamax—even if they had stopped taking it—were at higher risk for atrial fibrillation, a heart rhythm problem. This may be due to inflammation or decreases in calcium and phosphate levels, affecting how blood flows through arteries.
My thoughts: I recommend patients avoid taking Fosamax and other osteoporosis drugs in the bisphosphonate family. There are ways to increase bone density and strength without drugs. I recommend a pH-balanced diet.. walking or other regular weight-bearing exercise... supplementing with bone-enhancing nutrients, such as calcium, magnesium, vitamin D and the mineral strontium daily...and addressing deficiencies in hormones, such as testosterone (especially important for postmenopausal women, who are at greatest risk for osteoporosis).
Monthly Osteoporosis Pill
Approved A once-a-month, 150-mg tablet of risedronate (Actonel) for prevention and treatment of postmenopausal osteoporosis is now FDA-approved. A recent study showed similar increases in bone mineral density (BMD) between patients taking monthly doses and those taking the approved daily dose, which was previously shown to decrease the risk for fractures. Monthly users were more likely to experience diarrhea as a side effect.
Also recently approved: A once-yearly osteoporosis drug, zoledronic acid (Reclast), given intravenously.
Cholesterol Drugs Do Not Strengthen Bones
Some preliminary research suggested that cholesterol-lowering statin drugs, such as atorvastatin (Lipitor), had beneficial effects on the skeleton.
But: A new clinical study of postmenopausal women found that Lipitor had no effect, either positive or negative, on bone mineral density.
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