In a study of 22 menwith diabetes, more than 84% of ulcers treated with topical tretinoin (Retin-A), a popular acne medication, and antibacterial cadexomer iodine gel shrunk by at least half. In the group treated with a placebo solution and cadexomer iodine gel, 45.4% of ulcers shrunk by half.

Theory: Tretinoin stimulates blood vessel growth, which helps deliver oxygen to the wound site. Left untreated, diabetic ulcers may increase risk for amputation.

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