Overall, thiazolidinediones (TZDs), such as rosiglitazone (Avandia) and pioglitazone (Actos), raise heart-failure risk by 42%. Overall, dipeptidyl peptidase-4 (DPP-4) inhibitors, including saxagliptin and alogliptin, raise heart-failure risk by about 25%.
Good news: If you are overweight, losing weight to control blood sugar reduces the risk.
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